Star for star and grade for grade, there seem to be only 2 heroes who are able to burst down Nightingale’s self-healing skin: Panzer and Dogface. Paired with the relevant support cast a skinned Nightingale has enough health, armor and can self-heal while she is taking damage from either of these 2 mech heroes.
There has been alot of talk about whether Panzer ought to be nerfed further by reducing her clip size. What I can pretty safely say is that after thorough testing with friends, limiting Panzer’s clip to 16 rounds will mean that she will not be able to take down an appropriately set-up skinned Nightingale (with the equivalent stars and grade as Panzer).
Night will have just enough health to survive and while Panzer reloads (which takes a long time) Night and her support cast will heal her up. What support cast? Well there are at least 3 or 4 known configurations of heroes who were buffed this patch.
As for Dogface, there is only a limited window of opportunity for him to take down a skinned Night. His skills need time to charge up and therefore he engages only at the 30 second mark or so (depending on how you pilot him)… but at this time the support cast have their heals on standby or are already in the process of mid-heals.
By the way, I am not advocating for anything so please don’t attack me. I am just pointing out my observations. If you have the same or different experiences by all means share them.